Current projects
Phosphate Dysregulation in Cancer
Did you know that phosphate can be selectively toxic in cancer? We recently identified that a common feature of ovarian cancer is excessive flux of phosphate. In this context, inhibiting the cellular phosphate exporter XPR1 is selectively toxic to these cancers. We are exploring this theme to benefit ovarian cancer patients and expanding our view to other cancers with dysregulated phosphate homeostasis.
Exploring the logic of nutrient transporter networks
Our work studying phosphate homeostasis in cancer has revealed how little we know about the interconnected, redundant, and coordinate regulation of transporter networks. Nutrient transporters are the gatekeepers of cellular communication with the environment, controlling metabolism and signaling. How do they all work together?
Target Protein Degradation:
We want to make conditional degron tags the go-to tool for early target validation and for exploring your proteins of interest.
We published a lot of plasmids: find them on Addgene!
Daniel Bondeson
[email protected]
368 Plantation Street
Office AS6.2055
Worcester MA, 01605
Bondeson Lab
368 Plantation Street
Lab AS6.2013
Worcester MA 01605
