BondesonLab.org coming soon!
Welcome to the temporary website for the Bondeson Lab, which opened in September 2024 within the Department of Systems Biology at UMass Chan Medical School.
We use chemical biology and functional genomics to interrogate nutrient transporters and homeostasis in cancer. Interested? We're now recruiting graduate students, research associates, and postdocs.
Some example projects in the lab:
- We recently identified that the XPR1 phosphate efflux requires a partner protein: KIDINS220. Using saturating mutagenesis, we will ask how these proteins are regulated, how they interact with each other, and how they achieve phosphate efflux.
- Every cell expresses multiple phosphate transporters which are controlled transcriptionally and post-translationally. How does a cell ‘decide’ which proteins to regulate, and when? By developing multiplexed immunofluorescence assays, we will probe how these different transporter proteins are regulated in response to different perturbations (drugs and genetic knockouts).
- Why do cancers alter phosphate homeostasis, and how does increased phosphate transport alter cell state? Using approaches derived from the targeted protein degradation field, we will generate model systems with tunable levels of phosphate flux and study the transcriptional, metabolic, and pro-tumorigenic responses to altered phosphate flux.
About the PI:
Daniel Bondeson recently joined the Department of Systems Biology at UMass Chan as an Assistant Professor. His training spans chemistry and genomics:
- B.S. in Chemistry, University of Wisconsin - Stevens Point
- PhD with Dr. Craig Crews, Yale University
- Postdoc with Dr. Todd Golub, Broad Institute
Contact: [email protected]
Visit: Albert Sherman Center, 7th floor
Office AS7-1053
Lab AS7-1003